Synconvergent extension within orogenic systems is often interpreted as gravitational spreading of thickened crust or as a response to thrust belt dynamics. However, the processes that spatially localize extension during orogenesis are not fully understood. Here, a case study from the United States Cordillera demonstrates that localized upper-crustal thickening can exert a first-order control on the spatial location of synorogenic extension. The Eureka culmination, a 20-km-wide, north-trending anticline with 4.5 km of structural relief in the hinterland plateau of the Sevier orogenic belt (or “Nevadaplano”) in eastern Nevada was deformed by two sets of north-striking normal faults that pre-date late Eocene volcanism. (U-Th)/He and fission-track thermochronology data collected from Paleozoic quartzite in the footwalls of two normal faults demonstrate rapid (10 °C/m.y.), Late Cretaceous to Paleocene (75–60 Ma) cooling, which we interpret as tectonic exhumation during extension, and which was concurrent with late-stage shortening in the frontal Sevier thrust belt. This example illustrates that structural and topographic relief generated within zones of localized uppercrustal thickening can spatially focus extension during orogenesis, and adds to a growing body of evidence that Late Cretaceous–Paleocene extension in the Nevadaplano occurred at both mid- and upper-crustal levels.