| Antibiotic | Year marketed |
Year Resistance first observed |
| Sulfonamides | 1930 | 1940 |
| Penicillin | 1943 | 1946 |
| Sterptomycin | 1943 | 1959 |
| Chloramphenicol | 1947 | 1959 |
| Tetracycline | 1948 | 1959 |
| Erythromycin | 1952 | 1988 |
| Methicillin | 1960 | 1961 |
| Ampicillin | 1961 | 1973 |
| Cephalosporins | 1960s | late 1960s |
| ave | 11.3 | |
|
Palumbi, S.R. 2001. Humans as the World's Greatest Evolutionary Force. Science 293: 1786-1790. | ||